US researchers discover mobile source of recurrent glioblastoma
Researchers at the University of California, San Francisco (United States) have determined how most cancer cells evade targeted therapy through an escape mechanism
known as phenotype switching, likely explaining the failure of precision therapies. for orientation. glioblastoma to this point.
Glioblastoma is a type of incurable brain cancer with a median survival rate of less than years.
The tumors are especially resistant to treatment and difficult to operate on due to their location within the brain.
Preferred care for the disorder generally involves a safe maximal resection followed by radiation therapy and chemotherapy.
However, compliance costs are low, and tumors generally tend to recur.
In a Nature Cancer report, scientists from the United States of America have identified a probable cause of the recurrence.
Using 86 paired samples from patients with recurrent primary glioblastomas from a group of US biobanks containing tumor tissue